Voxelized simulation of cerebral oxygen perfusion elucidates hypoxia in aged mouse cortex

Departures of normal blood flow and metabolite distribution from the cerebral microvasculature into neuronal tissue have been implicated with age-related neurodegeneration. Mathematical models informed by spatially temporally distributed neuroimage data are becoming instrumental for reconstructing a coherent picture pathological oxygen delivery throughout brain. Unfortunately, current mathematical exchange become excessively large in size. They further suffer boundary effects due to incomplete or physiologically inaccurate computational domains, numerical instabilities enormous length scale differences, convergence problems associated condition number deterioration at fine mesh resolutions. Our proposed simple finite volume discretization scheme microperfusion simulations does not require expensive generation leading critical benefit that it drastically reduces matrix size bandwidth coupled transfer problem. The compact problem formulation yields rapid stable convergence. Moreover, can effectively be suppressed generating very replica cortical microcirculation silico using an image-based cerebrovascular network synthesis algorithm, so boundaries perfusion far removed regions interest. Massive over sizeable portions cortex feature resolution down micron tractable even modest computer resources. feasibility accuracy novel method is demonstrated validated vivo cohorts young aged mice. quantify steep gradients near penetrating vessels point towards changes might cause neurodegeneration brains. This research aims explain mechanistic interactions between anatomical structures how they change diseases age. Rigorous quantification significant interest because aide search imaging biomarkers dementia Alzheimer’s disease.